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An amount of 9-iodo-minocycline (free-base) (5.00g, 8.57mmol), trans-dichlorobis-(triphenylphosphine)palladium(II) (152mg, 0.22mmol), palladium(II)acetate (55mg, 0.24mmol), copper(I)iodide (92mg, 0.48mmol)were loaded in anhydrous acetonitrile (86mL) in a flame-dried 100mL round bottom flask equipped with a magnetic stirring bar.
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